Review Experimental neurology 2012

Hyperbaric oxygen therapy: can it prevent irradiation-induced necrosis?

Kuffler DP — Experimental neurology, 2012

View Original on PubMed PMID 22465460

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This review examined the potential of hyperbaric oxygen therapy (HBOT) to prevent or mitigate neurological side effects caused by cranial irradiation.

What They Found

While radiosurgery has a high success rate of approximately 95%, about 5% of patients experience neurological problems due to irradiation-induced inflammation. Existing studies suggest that hyperbaric oxygen therapy (HBOT) administered after the onset of these neurological side effects can reduce their incidence and severity.

Canadian Relevance

This review article does not have a direct Canadian connection.

Study Limitations

As a review, this study synthesizes existing literature and highlights that the exact mechanisms of irradiation-induced damage and HBOT's effects are still not fully understood.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Review
Category	Radiation Injury
Source	Pubmed
PubMed ID	22465460
Year Published	2012
Journal	Experimental neurology
MeSH Terms	Animals; Brain; Cranial Irradiation; Humans; Hyperbaric Oxygenation; Inflammation; Necrosis; Radiation Injuries

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology