What Researchers Did
Clinicians reported a case of doxorubicin (chemotherapy drug) extravasation causing severe forearm tissue injury in a 17-month-old infant being treated for rhabdomyosarcoma, managed with fasciotomy followed by HBOT.
What They Found
Following initial surgical decompression, HBOT was used to manage the ongoing tissue injury from doxorubicin toxicity, with the case resolving successfully. The authors note that limited access to the standard antidote (dexrazoxane) makes HBOT a valuable alternative treatment option.
Canadian Relevance
No direct Canadian connection identified. Access to dexrazoxane in Canada may be limited, making knowledge of alternative treatments like HBOT clinically relevant.
Study Limitations
Single case report in an infant; outcomes cannot be generalized given the highly specific combination of patient age, drug, injury location, and treatment sequence.