What Researchers Did
Researchers conducted a systematic literature review from 1960 to 2004 to evaluate hyperbaric oxygen therapy for radio-induced lesions in normal tissues, including complications in the head and neck, pelvis, nervous system, and prevention after surgery.
What They Found
Despite a small number of controlled trials, the review suggests hyperbaric oxygen therapy may be indicated for treating mandibular osteoradionecrosis in combination with surgery, haemorrhagic cystitis resistant to conventional treatments, and preventing osteoradionecrosis after dental extraction. The level of evidence for these specific indications appears significant, though further randomized trials are needed.
What This Means for Canadian Patients
Canadian patients experiencing severe late complications from radiotherapy, such as mandibular osteoradionecrosis or resistant haemorrhagic cystitis, might benefit from hyperbaric oxygen therapy as a treatment option. It could also help prevent osteoradionecrosis following dental extractions in previously irradiated areas.
Canadian Relevance
This literature review has no direct Canadian connection.
Study Limitations
A significant limitation is the small number of controlled trials available, highlighting the need for more randomized studies to solidify the evidence for hyperbaric oxygen therapy.