Hyperbaric oxygen therapy is effective and safe for femoral head osteonecrosis: a prospective midterm outcome study | Canada Hyperbarics Skip to main content
Prospective Study Eur J Orthop Surg Traumatol 2025

Hyperbaric oxygen therapy is effective and safe for femoral head osteonecrosis: a prospective midterm outcome study

Ansari S, Gaurav A, Gupta T, Bondarde P, Sri Madhusudan C, Mago V, et al. — Eur J Orthop Surg Traumatol, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers followed 35 patients with early-stage osteonecrosis of the femoral head (ONFH), bone death in the hip, who received 35 sessions of HBOT over 7 weeks and were then monitored with MRI and clinical tests for up to two years.

What They Found

At the two-year follow-up, Harris Hip Scores (function/pain) improved significantly (p = 0.001), as did VAS pain scores (p = 0.001). MRI findings also improved: lesion classification (JIC), bone lesion size (Modified Kerboul Angle), and bone marrow edema severity all improved significantly (all p ≤ 0.03). No serious side effects from HBOT were reported.

What This Means for Canadian Patients

Osteonecrosis of the femoral head can progress to hip collapse requiring total hip replacement if left untreated or treated too late. This study shows HBOT can produce real, measurable improvements in both pain and MRI findings over two years, offering Canadians with early-stage ONFH a non-surgical option worth pursuing before considering joint replacement. This is particularly relevant to younger patients who want to delay or avoid surgery.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This prospective study had no control group and only 35 patients, so results may reflect natural disease variation or placebo effect rather than HBOT's direct impact alone.

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Study Details

Study Type Prospective Study
Category Aging & Longevity
Source Pubmed
PubMed ID 40751751
Year Published 2025
Journal Eur J Orthop Surg Traumatol
MeSH Terms Humans; Hyperbaric Oxygenation; Femur Head Necrosis; Male; Female; Prospective Studies; Adult; Magnetic Resonance Imaging; Middle Aged; Treatment Outcome; Follow-Up Studies; Radiography; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.