Hyperbaric oxygen treatment for chronic insomnia at high altitude: A prospective, randomized, open-label, parallel-group trial | Canada Hyperbarics Skip to main content
RCT Travel Med Infect Dis 2025

Hyperbaric oxygen treatment for chronic insomnia at high altitude: A prospective, randomized, open-label, parallel-group trial

Sun B, He J, Chen H, Zeng W, Tian T, Abay M, et al. — Travel Med Infect Dis, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a randomized controlled trial in China assigning 80 patients with chronic insomnia at high altitude to either 10 days of hyperbaric oxygen treatment or standard care, measuring sleep quality, fatigue, anxiety, and depression.

What They Found

The HBOT group showed significantly better sleep quality scores after treatment compared to the control group (PSQI score: 4.6 vs. 9.1; p < 0.0001). The Insomnia Severity Index was also significantly lower in the HBOT group (5.0 vs. 9.8; p < 0.0001). The HBOT group also reported improvements in fatigue, anxiety, and depression. No serious side effects were reported in either group.

What This Means for Canadian Patients

While this study was conducted at high altitude, a specific physiological context less common in most of Canada, the results suggest HBOT can meaningfully improve sleep in patients where low oxygen availability contributes to insomnia. Canadians in high-altitude regions or those with oxygen-related sleep disturbances may benefit from exploring this treatment.

Canadian Relevance

No direct Canadian connection identified. Chronic insomnia is not an OHIP-covered indication for HBOT.

Study Limitations

The open-label design means patients knew which treatment they received, introducing potential placebo bias; also, high-altitude insomnia may not respond the same as sea-level insomnia.

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Study Details

Study Type RCT
Category Uncategorised
Source Pubmed
PubMed ID 40089167
Year Published 2025
Journal Travel Med Infect Dis
MeSH Terms Humans; Sleep Initiation and Maintenance Disorders; Male; Hyperbaric Oxygenation; Female; Adult; Altitude; Prospective Studies; Treatment Outcome; Young Adult; Chronic Disease; Sleep Quality

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.