RCT Diving and hyperbaric medicine 2021

Hyperbaric oxygen treatment for mastectomy flap ischaemia: A case series of 50 breasts.

Spruijt NE, Hoekstra LT, Wilmink J, Hoogbergen MM — Diving and hyperbaric medicine, 2021

View Original on PubMed PMID 33761535

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers retrospectively analyzed outcomes of hyperbaric oxygen treatment (HBOT) in 50 breasts with mastectomy flap ischaemia to evaluate its effectiveness in a case series.

What They Found

Hyperbaric oxygen treatment (HBOT) was initiated a median of 3 days post-surgery for a median of 12 sessions. The breast skin surface area scores improved in 34% of observations, and 29 breasts (58%) recovered without additional surgery. Pre-operative radiotherapy (OR 7.2) and postoperative infection (OR 15.4) were identified as significant risk factors for re-operation.

Canadian Relevance

This study does not have a direct Canadian connection as it was conducted outside of Canada.

Study Limitations

A key limitation of this study is its retrospective case series design, which limits the ability to establish causality and control for confounding factors.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Infection
Source	Pubmed
PubMed ID	33761535
Year Published	2021
Journal	Diving and hyperbaric medicine
MeSH Terms	Breast Neoplasms; Humans; Hyperbaric Oxygenation; Mammaplasty; Mastectomy; Oxygen; Postoperative Complications; Retrospective Studies; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology