Clinical Study Annals of the New York Academy of Sciences 2010

Hyperbaric oxygen treatment induces antioxidant gene expression.

Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE — Annals of the New York Academy of Sciences, 2010

View Original on PubMed PMID 20536847

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers analyzed global gene expression changes in human endothelial cells following a hyperbaric oxygen exposure comparable to a clinical treatment.

What They Found

Their analysis revealed an upregulation of antioxidant, cytoprotective, and immediate early genes in the treated cells. This increase coincided with an increased resistance to a lethal oxidative stress.

Canadian Relevance

This study has no specific Canadian connection.

Study Limitations

A key limitation is that this research was conducted in vitro using human endothelial cells rather than in living patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Wound Care
Source	Pubmed
PubMed ID	20536847
Year Published	2010
Journal	Annals of the New York Academy of Sciences
MeSH Terms	Aging; Animals; Antioxidants; Caloric Restriction; Endothelial Cells; Exercise; Gene Expression; Hot Temperature; Humans; Hyperbaric Oxygenation; Male; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species

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This study relates to Problem Wounds. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology