What Researchers Did
Researchers measured plasma cytokine levels in 242 patients with necrotizing soft-tissue infection (NSTI) upon admission, daily for three days, and before and after hyperbaric oxygen (HBO) treatment.
What They Found
Hyperbaric oxygen (HBO) treatment was associated with a significant decrease in plasma levels of TNF-α (p < 0.001), IL-6 (p < 0.001), and G-CSF (p < 0.001). The reduction in IL-6 was more pronounced in patients who received multiple HBO treatments (p = 0.002), while IL-1β and IL-10 levels showed no significant changes.
Canadian Relevance
This study was not conducted in Canada and therefore has no direct Canadian connection.
Study Limitations
The study primarily focused on cytokine levels and did not directly assess the impact of these changes on clinical progression or patient outcomes.