[Hyperbaric oxygenation and antianginal agents: effects on blood levels of malondialdehyde and activities of antioxidative enzymes in patients with ischemic heart disease].

What Researchers Did

Researchers assessed the impact of hyperbaric oxygenation combined with antianginal agents on oxidative stress markers and clinical symptoms in 38 patients with stable angina, compared to 26 patients receiving hyperbaric oxygenation alone.

What They Found

The study found that a positive clinical effect from hyperbaric oxygenation was associated with increased superoxide dismutase activity in red blood cells. Specifically, the use of nifedipine in the 38 patients receiving multimodality therapy prevented the hyperbaric oxygenation-induced rise in serum malonic dialdehyde levels.

What This Means for Canadian Patients

For Canadian patients with stable angina, these findings suggest that hyperbaric oxygenation, particularly when combined with nifedipine, may help manage oxidative stress and improve clinical outcomes. This could potentially be considered as an adjunctive therapy to standard antianginal treatments.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in Russia.

Study Limitations

The study's limitations include a relatively small sample size and the absence of detailed quantification for the reported clinical improvements.