Innovative Use of dHACM in Conjunction With Hyperbaric Oxygen Therapy to Treat a Nonhealing Nasal Wound Subsequent to Squamous Cell Carcinoma Resection and Radiation: A Case Study. | Canada Hyperbarics Skip to main content
Clinical Study Wounds : a compendium of clinical research and practice 2019

Innovative Use of dHACM in Conjunction With Hyperbaric Oxygen Therapy to Treat a Nonhealing Nasal Wound Subsequent to Squamous Cell Carcinoma Resection and Radiation: A Case Study.

Henderson JA, Jones MW, Houle SS — Wounds : a compendium of clinical research and practice, 2019

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers documented the case of a 75-year-old man with a nonhealing nasal wound following squamous cell carcinoma resection and radiation, treated with hyperbaric oxygen therapy and dehydrated human amnion/chorion membrane (dHACM) grafting.

What They Found

After initial hyperbaric oxygen therapy, a dHACM graft was applied, leading to a 45% decrease in defect size after four applications. This combined approach ultimately resulted in complete reepithelialization and resolution of the patient's symptoms.

Canadian Relevance

This study does not have a direct Canadian connection as it was not conducted in Canada or by Canadian researchers.

Study Limitations

As a single case study, the findings cannot be generalized to a broader patient population.

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Study Details

Study Type Clinical Study
Category Wound Care
Source Pubmed
PubMed ID 30924794
Year Published 2019
Journal Wounds : a compendium of clinical research and practice
MeSH Terms Aged; Allografts; Amnion; Carcinoma, Squamous Cell; Chorion; Debridement; Humans; Hyperbaric Oxygenation; Male; Nose Neoplasms; Treatment Outcome; Wound Healing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology