LDL-apheresis dramatically improves generalized calciphylaxis in a patient undergoing hemodialysis. | Canada Hyperbarics Skip to main content
Clinical Study Clinical nephrology 2014

LDL-apheresis dramatically improves generalized calciphylaxis in a patient undergoing hemodialysis.

Iwagami M, Mochida Y, Ishioka K, Oka M, Moriya H, Ohtake T, et al. — Clinical nephrology, 2014

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers documented the first case of generalized calciphylaxis that dramatically improved after low-density lipoprotein-apheresis (LA) in a patient undergoing long-term hemodialysis.

What They Found

The patient presented with painful ulcers on the right leg, left buttock, and glans penis, along with markedly reduced skin perfusion pressure (SPP), despite various conventional treatments. After introducing LA, SPP dramatically increased, and the ulcers healed, demonstrating LA's potential as a treatment option.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

As a single case report, the findings of this study cannot be generalized to a broader patient population.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Wound Care
Source Pubmed
PubMed ID 23036228
Year Published 2014
Journal Clinical nephrology
MeSH Terms Aged; Blood Component Removal; Calciphylaxis; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Renal Dialysis; Skin Ulcer; Time Factors; Treatment Outcome; Wound Healing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology