What Researchers Did
Researchers measured linezolid penetration into wound tissue in two diabetic patients with lower-extremity ulcers before and after hyperbaric oxygen therapy.
What They Found
Initially, linezolid penetration into wound tissue was 0.474 for Patient 1 and 0.479 for Patient 2. Following hyperbaric oxygen therapy, penetration improved to 0.950 for Patient 1 and 0.757 for Patient 2.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
A significant limitation of this study is the very small sample size of only two patients, limiting generalizability.