What Researchers Did
Researchers systematically reviewed 58 studies to assess the efficacy of locoregional treatments for digital ulcers in systemic sclerosis.
What They Found
Among the different strategies, injections of fat-derived cells and botulinum toxin showed promising results in reducing pain and the number of digital ulcers. Conversely, sympathectomy yielded disappointing results with low effectiveness and frequent recurrence. For other treatments like hyperbaric oxygen therapy and phototherapy, the review found conflicting results or limited published data.
What This Means for Canadian Patients
Canadian patients with digital ulcers in systemic sclerosis might consider discussing locoregional treatments such as fat-derived cell injections or botulinum toxin with their specialists. However, they should be aware that other therapies, like sympathectomy, showed less promising outcomes.
Canadian Relevance
This systematic review did not include any specific Canadian connection or data.
Study Limitations
The review noted that many locoregional treatments had conflicting results or limited published data, reflecting a low level of evidence.