Clinical Study Journal of the neurological sciences 1998

Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning.

Yoshii F, Kozuma R, Takahashi W, Haida M, Takagi S, Shinohara Y — Journal of the neurological sciences, 1998

View Original on PubMed PMID 9804123

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers repeatedly performed magnetic resonance imaging (MRI) and 11C-N-methylspiperone/positron emission tomography (PET) imaging on a 50-year-old man with the interval form of carbon monoxide poisoning.

What They Found

Two months after poisoning, MRI showed high signal intensities in the globus pallidus, and PET revealed increased dopamine D2 receptor binding in the caudate and putamen. Treatment with bromocriptine was effective, and by five months post-poisoning, imaging showed improvement alongside the resolution of neuropsychiatric symptoms.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A significant limitation of this study is that it reports findings from only a single patient, limiting generalizability.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Carbon Monoxide Poisoning
Source	Pubmed
PubMed ID	9804123
Year Published	1998
Journal	Journal of the neurological sciences
MeSH Terms	Basal Ganglia; Bromocriptine; Carbon Monoxide Poisoning; Carbon Radioisotopes; Caudate Nucleus; Cerebral Hemorrhage; Combined Modality Therapy; Convalescence; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Globus Pallidus; Humans; Hyperbaric Oxygenation; Levodopa; Magnetic Resonance Imaging

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This study relates to Carbon Monoxide Poisoning. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology