Review Brachytherapy 2013 Canadian

Management of Bartholin's gland carcinoma using high-dose-rate interstitial brachytherapy boost.

Thibault I, Lavallée MC, Aubin S, Jain S, Laflamme N, Vigneault É — Brachytherapy, 2013

View Original on PubMed PMID 23406985

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed the patterns of use, clinical outcomes, and dose-volume histogram parameters of high-dose-rate interstitial brachytherapy (HDR-ISBT) as a boost in five patients with Stage II-III Bartholin's gland carcinoma.

What They Found

All 5 patients received HDR-ISBT as a boost (median dose, 30Gy) after external beam radiotherapy (median dose, 45Gy). A complete response was observed in all patients, with no local recurrence and all remaining alive and free of disease after a median follow-up of 78 months. Severe vaginal toxicities, including necrosis, were noted but resolved with hyperbaric oxygen therapy.

Canadian Relevance

The study's authors are Canadian, indicating direct relevance to Canadian medical practice and research in oncology.

Study Limitations

A significant limitation of this study is the very small sample size of only five patients, which limits the generalizability of the findings.

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Study Details

Study Type	Review
Category	Radiation Injury
Source	Pubmed
PubMed ID	23406985
Year Published	2013
Journal	Brachytherapy
MeSH Terms	Bartholin's Glands; Brachytherapy; Dose-Response Relationship, Radiation; Female; Follow-Up Studies; Humans; Middle Aged; Radiotherapy, High-Energy; Vulvar Neoplasms

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology