Clinical Study Annales chirurgiae et gynaecologiae 1999

Management of clostridial gas gangrene and the role of hyperbaric oxygen.

Korhonen K, Klossner J, Hirn M, Niinikoski J — Annales chirurgiae et gynaecologiae, 1999

View Original on PubMed PMID 10392252

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the efficacy of surgery, antibiotic treatment, surgical intensive care, and hyperbaric oxygen (HBO) in the management of clostridial gas gangrene in 53 patients.

What They Found

All 53 patients received surgical debridement, broad-spectrum antibiotics, and a series of hyperbaric oxygen treatments at 2.5 ATA. Twelve patients died, resulting in a mortality rate of 22.6%. Hyperbaric oxygen therapy decreased systemic toxicity and prevented further infection extension, improving overall patient outcomes.

Canadian Relevance

The study was conducted in Finland and has no direct Canadian connection.

Study Limitations

The abstract does not specify a control group, making it difficult to isolate the independent effect of hyperbaric oxygen therapy.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Infection
Source	Pubmed
PubMed ID	10392252
Year Published	1999
Journal	Annales chirurgiae et gynaecologiae
MeSH Terms	Adult; Aged; Amputation, Surgical; Anti-Bacterial Agents; Combined Modality Therapy; Debridement; Female; Gas Gangrene; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Postoperative Complications; Reoperation; Survival Rate

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology