What Researchers Did
This review article defined radiation response modifiers and assessed their clinical value, highlighting major problems in their testing and application.
What They Found
The review identified significant challenges in clinically testing radiation response modifiers, primarily due to the heterogeneity of patient material. Disappointing results were noted from studies involving misonidazole, yet the potential for new hypoxic cell sensitizers remains promising if higher efficacy can be achieved. The author emphasized the need for clinical trials to verify previous findings and to develop methods for identifying patients most likely to benefit from specific modifiers.
Canadian Relevance
This study has no direct Canadian connection as it is a general review of radiation response modification without specific Canadian data or authors.
Study Limitations
A significant limitation identified is the inherent heterogeneity of clinical material, which poses a major, quantitatively undefined problem for the reliable testing of radiation response modifiers.