What Researchers Did
Researchers monitored 369 oxygen tolerance tests, including cerebral blood flow velocity (CBFV) in 61 cases, to investigate the predictability of central nervous system (CNS) toxicity.
What They Found
Early manifestations of CNS toxicity occurred in 11 of 369 tests within 22 ± 3 minutes, with 6 cases of twitches/agitation and 5 of tonic-clonic seizures. In the two cases with CBFV monitoring where symptoms appeared, an increase in CBFV preceded symptom onset, once followed by a seizure and once prevented by timely oxygen reduction.
Canadian Relevance
This study has no direct Canadian connection or specific relevance to Canadian healthcare policy or patient populations.
Study Limitations
A significant limitation is the very small number of cases (only two) where cerebral blood flow velocity was correlated with the onset of CNS toxicity.