Retrospective Study Anaesthesia and intensive care 2015

Necrotising soft tissue infections: the effect of hyperbaric oxygen on mortality.

Devaney B, Frawley G, Frawley L, Pilcher DV — Anaesthesia and intensive care, 2015

View Original on PubMed PMID 26603791

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

In a single-centre, retrospective, case-controlled study, researchers assessed the effect of hyperbaric oxygen therapy (HBOT) on mortality in 341 patients with necrotising fasciitis over a 13-year period.

What They Found

Overall mortality was 14.4%, with 12% in patients treated with HBOT compared to 24.3% in those not treated. HBOT was independently associated with a significant reduction in mortality (odds ratio 0.42, P=0.01), even after adjusting for illness severity. Increased age and immunosuppression were also independent factors impacting mortality.

Canadian Relevance

This study was conducted in Australia and does not have a direct Canadian connection.

Study Limitations

The retrospective, single-centre design of this study limits the generalizability of its findings and introduces potential for selection bias.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Retrospective Study
Category	Infection
Source	Pubmed
PubMed ID	26603791
Year Published	2015
Journal	Anaesthesia and intensive care
MeSH Terms	Adult; Aged; Aged, 80 and over; Case-Control Studies; Fasciitis, Necrotizing; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Soft Tissue Infections

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology