New aspects on the pathophysiology of wound infection and wound healing--the problem of lowered oxygen pressure in the tissue. | Canada Hyperbarics Skip to main content
Clinical Study Infection 1985

New aspects on the pathophysiology of wound infection and wound healing--the problem of lowered oxygen pressure in the tissue.

Kühne HH, Ullmann U, Kühne FW — Infection, 1985

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed the correlation between tissue oxygen tension, wound infection, and healing, and introduced tetrachlorodecaoxide (TCDO) as a new topical oxygen carrier for hypoxic wounds.

What They Found

They found a strong correlation between tissue oxygen tension and the incidence of wound infection and impaired healing, noting that both infection and repair processes consume oxygen. Animal experiments demonstrated that adequate tissue oxygenation is essential for pathogen elimination, phagocytosis, and tissue regeneration. A new oxygen carrier, tetrachlorodecaoxide (TCDO), was introduced as a novel topical treatment concept for infected hypoxic wounds.

Canadian Relevance

This study has no direct Canadian connection, as it was conducted internationally and does not involve Canadian researchers, institutions, or patient populations.

Study Limitations

A limitation is that this paper primarily reviews existing knowledge and animal experiments, introducing a therapeutic concept without presenting specific human clinical trial data for tetrachlorodecaoxide (TCDO).

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Wound Care
Source Pubmed
PubMed ID 3838970
Year Published 1985
Journal Infection
MeSH Terms Animals; Chlorine; Free Radicals; Granulomatous Disease, Chronic; Humans; Leukocytes; Oxides; Oxygen; Oxygen Consumption; Partial Pressure; Phagocytosis; Wound Healing; Wound Infection

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology