What Researchers Did
Researchers reviewed the current understanding of osteoradionecrosis of the mandible, a serious complication of radiation therapy for head and neck cancers.
What They Found
The review highlighted a shift in understanding osteoradionecrosis pathogenesis from vascular insufficiency to a fibroatrophic mechanism. A double-blinded, placebo-controlled study found no benefit from hyperbaric oxygen for advanced osteoradionecrosis of the mandible. Restoration of blood supply or vascularized tissue remains crucial for resolution.
What This Means for Canadian Patients
Canadian patients undergoing radiation therapy for head and neck cancers should be aware of osteoradionecrosis as a potential complication. For advanced cases of osteoradionecrosis of the mandible, this review suggests that hyperbaric oxygen therapy may not be an effective treatment option. Instead, treatment strategies focusing on restoring blood supply to the affected area are emphasized.
Canadian Relevance
Osteoradionecrosis is a Health Canada-recognized indication for hyperbaric oxygen therapy. However, this review highlights research suggesting no benefit from HBOT for advanced cases of mandibular osteoradionecrosis, which is important for Canadian practitioners and patients to consider.
Study Limitations
As a review article from 2005, this summary reflects the understanding and available research on osteoradionecrosis of the mandible at that time.