Partial hypoxia as a cause of radioresistance in a human tumor xenograft: its influence illustrated by the sensitizing effect of misonidazole and hyperbaric oxygen. | Canada Hyperbarics Skip to main content
Clinical Study International journal of radiation oncology, biology, physics 1986

Partial hypoxia as a cause of radioresistance in a human tumor xenograft: its influence illustrated by the sensitizing effect of misonidazole and hyperbaric oxygen.

Reynaud-Bougnoux A, Lespinasse F, Malaise EP, Guichard M — International journal of radiation oncology, biology, physics, 1986

View Original on PubMed PMID 3759547
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the influence of misonidazole and hyperbaric oxygen on the radioresistance of HRT18 human tumour xenografts in mice.

What They Found

Both misonidazole (MISO) and hyperbaric oxygen (HBO) sensitized HRT18 tumour cells to radiation, supporting the hypothesis of partially hypoxic cells in solid tumours. MISO treatment resulted in enhancement ratios of 1.7 at the 5.10(-1) level, 1.6 at the 10(-1) level, and 1.6 at the 10(-2) level. HBO yielded enhancement ratios of 1.7 at the 5.10(-1) level, 1.4 at the 10(-1) level, and 1.4 at the 10(-2) level.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study was conducted on human tumour xenografts in mice, which may not fully translate to human clinical outcomes.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Clinical Study
Category Wound Care
Source Pubmed
PubMed ID 3759547
Year Published 1986
Journal International journal of radiation oncology, biology, physics
MeSH Terms Animals; Combined Modality Therapy; Humans; Hyperbaric Oxygenation; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology