Review Head & neck 2015 Canadian

Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.

Glicksman JT, Khalili S, Fung K, Parnes LS, Agrawal SK — Head & neck, 2015

View Original on PubMed PMID 25821165

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reported a case of osteoradionecrosis of the temporal bone treated with a pentoxifylline-tocopherol-clodronate combination and reviewed existing literature.

What They Found

A 52-year-old woman developed osteoradionecrosis of the temporal bone 20 years after radiation therapy, failing conservative management. Her condition dramatically improved after treatment with the pentoxifylline-tocopherol-clodronate (PENTOCLO) combination. This was the first documented use of PENTOCLO for this specific condition.

Canadian Relevance

This study reports on a patient treated at a Canadian institution, demonstrating the potential for this novel treatment within the Canadian healthcare system.

Study Limitations

As a single case report and literature review, this study's findings are limited in generalizability and require further investigation in larger cohorts.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Review
Category	Radiation Injury
Source	Pubmed
PubMed ID	25821165
Year Published	2015
Journal	Head & neck
MeSH Terms	Bone Density Conservation Agents; Clodronic Acid; Drug Combinations; Female; Humans; Middle Aged; Osteoradionecrosis; Parotid Neoplasms; Pentoxifylline; Temporal Bone; Tocopherols; Treatment Outcome

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology