Review J Surg Res 2008

Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide?

Yogaratnam J, Laden G, Guvendik L, Cowen M, Cale A, Griffin S — J Surg Res, 2008

View Original on PubMed PMID 17996900

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This opinion review article synthesized existing evidence to suggest that hyperbaric oxygen (HBO2) could pharmacologically precondition and protect the myocardium from ischaemic reperfusion injury (IRI) during cardiac surgery.

What They Found

The review found that HBO2 treatment post-ischaemia and reperfusion is useful in ameliorating myocardial IRI. Preconditioning with HBO2 before reperfusion demonstrated a myocardial protective effect by limiting infarct size. This protection may be partly due to stimulating endogenous nitric oxide production, which reduces neutrophil sequestration and improves vascular flow.

Canadian Relevance

This review article has no direct Canadian connection.

Study Limitations

As an opinion review, this study synthesizes existing literature without presenting new experimental data or clinical trial results.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Review
Category	Cardiac
Source	Pubmed
PubMed ID	17996900
Year Published	2008
Journal	J Surg Res
MeSH Terms	Animals; Cardiac Surgical Procedures; Humans; Hyperbaric Oxygenation; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Nitric Oxide; Rats

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology