Pneumatosis cystoides intestinalis associated with intravenous pulse cyclophosphamide treatment for systemic lupus erythematosus | Canada Hyperbarics Skip to main content
Case Report Ryumachi 1998

Pneumatosis cystoides intestinalis associated with intravenous pulse cyclophosphamide treatment for systemic lupus erythematosus

Nonaka D, Higuchi M, Yoshizawa S, Horiuchi T, Nakashima H, Niho Y — Ryumachi, 1998

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reported on a single patient with systemic lupus erythematosus who developed a rare bowel condition called pneumatosis cystoides intestinalis after receiving intravenous cyclophosphamide.

What They Found

A 51-year-old woman with systemic lupus erythematosus developed pneumatosis cystoides intestinalis and air in her abdominal cavity after her second dose of intravenous cyclophosphamide. She was successfully treated over three weeks with intravenous nutrition and breathing high concentration oxygen, which resolved both conditions. This was the first case suggesting a link between intravenous cyclophosphamide and this bowel condition.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This study is a single case report, which limits the generalizability of its findings to a broader patient population.

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Study Details

Study Type Case Report
Category Uncategorised
Source Pubmed
PubMed ID 9785989
Year Published 1998
Journal Ryumachi
MeSH Terms Cyclophosphamide; Drug Administration Schedule; Female; Humans; Hyperbaric Oxygenation; Immunosuppressive Agents; Infusions, Intravenous; Lupus Erythematosus, Systemic; Middle Aged; Parenteral Nutrition, Total; Pneumatosis Cystoides Intestinalis

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology