Clinical Study Advanced healthcare materials 2025

Prodigiosin Loaded SN-PB@PG NPs-Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds.

Wu Z, Chang L, Li C, Xu P, Liu L, Tong A, et al. — Advanced healthcare materials, 2025

View Original on PubMed PMID 40123202

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers developed and tested SN-PB@PG nanocomplexes combined with near-infrared irradiation to treat bacterial-infected chronic wounds in diabetic animal models.

What They Found

The SN-PB@PG NPs with near-infrared irradiation reduced wound area to 10.6% by day 11, significantly better than the control group's 29.6%. In flap transplantation experiments, this treatment resulted in only 3.8% flap necrobiosis by day 8, compared to 31.3% in controls. Nitric oxide release also promoted vascular regeneration and tissue repair.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or with Canadian participants.

Study Limitations

The study was conducted using animal models, meaning further research is needed to confirm these findings and their safety and efficacy in human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Wound Care
Source	Pubmed
PubMed ID	40123202
Year Published	2025
Journal	Advanced healthcare materials
MeSH Terms	Prodigiosin; Animals; Wound Healing; Nanoparticles; Mice; Male; Nitric Oxide; Combined Modality Therapy; Anti-Bacterial Agents; Wound Infection; Humans; Bacterial Infections; Biofilms

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This study relates to Problem Wounds. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

See all Wound Care research

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology