Clinical Study Cancer letters 2003

Prophylactic hyperbaric oxygen treatment and rat spinal cord re-irradiation.

Sminia P, van der Kleij AJ, Carl UM, Feldmeier JJ, Hartmann KA — Cancer letters, 2003

View Original on PubMed PMID 12609710

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the prophylactic potential and optimal timing of hyperbaric oxygen (HBO) therapy on the re-irradiation tolerance of the cervical spinal cord in rats.

What They Found

In five groups of 10 rats, the cervical spinal cord was irradiated with 10 fractions of 6.5 Gy, followed by re-irradiation with a 20 Gy single dose one year later. Actuarial analysis showed no significant difference in neurological complications-free survival between irradiation alone and irradiation plus HBO treatment groups.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A key limitation is that findings from rat models may not directly translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Radiation Injury
Source	Pubmed
PubMed ID	12609710
Year Published	2003
Journal	Cancer letters
MeSH Terms	Animals; Brain Injuries; Cervical Vertebrae; Child; Cranial Irradiation; Dose Fractionation, Radiation; Female; Humans; Hyperbaric Oxygenation; Myelitis; Neoplasms, Radiation-Induced; Neovascularization, Physiologic; Paralysis; Radiation Injuries; Radiation Tolerance

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology