RCT Gan to kagaku ryoho. Cancer & chemotherapy 1986

Radiation sensitizers: with special reference to hypoxic cell sensitizers.

Onoyama Y, Nakajima T, Tanaka M — Gan to kagaku ryoho. Cancer & chemotherapy, 1986

View Original on PubMed PMID 3963856

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed various types of radiation sensitizers and their mechanisms for increasing cellular radiosensitivity in radioresistant tumours.

What They Found

They found that pyrimidine analogues can increase cellular radiosensitivity up to a factor of 3 by incorporating into DNA. However, clinical trials using intra-arterial infusion of BUdR showed unsatisfactory long-term survival. The review also highlighted the potential of hypoxic cell sensitizers to address the radioresistance of hypoxic tumour cells.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A significant limitation is that this is a review from 1986, meaning the information on clinical trials and experimental agents is outdated.

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Study Details

Study Type	RCT
Category	Radiation Injury
Source	Pubmed
PubMed ID	3963856
Year Published	1986
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
MeSH Terms	Animals; Bromodeoxyuridine; Cells, Cultured; Humans; Misonidazole; Neoplasms; Oxygen; Partial Pressure; Radiation-Sensitizing Agents

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology