Refractory postsurgical pyoderma gangrenosum in a patient with Beckwith Wiedemann syndrome: response to multimodal therapy.

What Researchers Did

Researchers presented a case report detailing the diagnosis and multimodal treatment of refractory postsurgical pyoderma gangrenosum in a 41-year-old woman.

What They Found

A 41-year-old woman developed progressive deep chest wall ulcerations after multiple surgeries, including bilateral reduction mammoplasty and mastectomy, which were diagnosed as pyoderma gangrenosum. She failed numerous treatments, including various immunomodulatory agents, surgical wound closure, and negative pressure wound therapy. Ultimately, a multimodal approach involving adalimumab, mycophenolate mofetil, prednisone, and hyperbaric oxygen therapy led to progressive healing.

Canadian Relevance

This study has no direct Canadian connection as it is a case report from outside Canada.

Study Limitations

As a single case report, the findings may not be generalizable to a broader patient population with pyoderma gangrenosum.