Safety of hyperbaric oxygen therapy in non-emergent patients with a history of seizures: A retrospective cohort study | Canada Hyperbarics Skip to main content
Cohort Study PLoS One 2025 Canadian

Safety of hyperbaric oxygen therapy in non-emergent patients with a history of seizures: A retrospective cohort study

Park S, Marinov A, Clarke H, Schiavo S, Greer E, Djaiani G, et al. — PLoS One, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers at Toronto General Hospital and Rouge Valley Hyperbaric Medical Center retrospectively reviewed 634 HBOT sessions administered to 22 patients with pre-existing seizure disorders to assess safety, with sessions lasting 90 to 120 minutes at 1.8 to 2.4 ATA with 5-minute air breaks.

What They Found

Only 1 seizure occurred in 634 treatment sessions (0.16% per session). 21 of the 43 referred patients chose not to proceed with treatment. Patients were managed at 1.8 ATA (n=3), 2.0 ATA (n=18), or 2.4 ATA (n=1); 15 were on antiseizure medications throughout.

Canadian Relevance

This is a Canadian study conducted at Toronto General Hospital and Rouge Valley Hyperbaric Medical Center in Ontario, directly relevant to Canadian HBOT practice. The safety data from these two Ontario facilities support including patients with controlled seizure disorders in HBOT programs.

Study Limitations

Small sample of 22 patients; the study excluded high-risk patients (21 did not proceed), so the observed seizure rate may underestimate risk in less carefully selected populations.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Cohort Study
Category Uncategorised
Source Pubmed
PubMed ID 39808603
Year Published 2025
Journal PLoS One
MeSH Terms Humans; Hyperbaric Oxygenation; Seizures; Retrospective Studies; Male; Female; Middle Aged; Adult; Aged; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology