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Systematic Review Undersea Hyperb Med 2025

Systematic Review of Otologic Adverse Events in Hyperbaric Oxygen Therapy

Voigt A, Laspro M, Thys E, Jethanamest D, Chiu E — Undersea Hyperb Med, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted the largest systematic review to date on ear-related side effects from HBOT, analyzing 54 studies involving 18,284 patients.

What They Found

Overall, 15% of patients experienced some form of ear problem during HBOT. Of middle ear barotrauma cases, 42.8% were mild and 6.4% were severe. Key risk factors were older age, being female, having head and neck conditions or sensory neuropathy, and difficulty equalizing ear pressure before treatment. Knowing proper equalization technique was the main protective factor.

What This Means for Canadian Patients

Most ear side effects from HBOT are mild and preventable. Canadian patients starting HBOT, especially older adults or those who have had head and neck cancer treatment, should be taught ear pressure equalization techniques before their first session to reduce their risk of complications.

Canadian Relevance

No direct Canadian connection identified, but this safety data is relevant to all Canadian HBOT centres, which should screen patients for risk factors before treatment begins.

Study Limitations

The 54 included studies varied widely in how they defined and measured ear complications, so the 15% figure reflects a range of severity levels that are not directly comparable across studies.

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Study Details

Study Type Systematic Review
Category Systematic Reviews
Source Pubmed
PubMed ID 41429031
Year Published 2025
Journal Undersea Hyperb Med
MeSH Terms Humans; Hyperbaric Oxygenation; Barotrauma; Risk Factors; Ear, Middle; Age Factors; Female; Sex Factors; Male; Protective Factors

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.