What Researchers Did
Researchers administered a single intraarterial infusion of 2.5 mg/kg bevacizumab after hyperosmotic blood-brain barrier disruption to two paediatric patients with medically intractable radiation necrosis following stereotactic radiosurgery.
What They Found
At a mean follow-up of 8.5 months, both paediatric patients (n=2) experienced significant clinical and radiographic improvement in their radiation necrosis. This targeted intraarterial approach aimed to reduce systemic complications, which are a concern with intravenous bevacizumab.
Canadian Relevance
This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian researchers or patients.
Study Limitations
The primary limitation of this study is its very small sample size, consisting of only two paediatric patients, which prevents generalization of the findings.