Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial. | Canada Hyperbarics
RCT BMJ open 2025

Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial.

Kjellberg A, Hassler A, Boström E, El Gharbi S, Al-Ezerjawi S, Schening A, et al. — BMJ open, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomised, placebo-controlled, double-blind trial in Sweden to evaluate if 10 sessions of hyperbaric oxygen treatment improved health-related quality of life, symptoms, and physical performance in 80 long COVID patients compared to sham treatment.

What They Found

Eighty subjects (65 women, 15 men) with long COVID were enrolled and randomised, with 40 receiving HBOT and 40 receiving sham treatment. At 13 weeks, both groups showed improvement from baseline, but there was no significant difference between the hyperbaric oxygen treatment and placebo groups in primary endpoints like physical functioning.

What This Means for Canadian Patients

Canadian patients with long COVID should not expect hyperbaric oxygen treatment to be a superior option for improving physical functioning or quality of life based on these results. Patients should continue to rely on evidence-based therapies and consult their healthcare providers for management strategies.

Canadian Relevance

This study has no direct Canadian connection as it was conducted at a single centre in Sweden.

Study Limitations

A key limitation is that this was a single-centre study, which may affect the generalizability of its findings to a broader population.

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Study Details

Study Type RCT
Category COVID-19 / Long COVID
Source Pubmed
PubMed ID 40228859
Year Published 2025
Journal BMJ open
MeSH Terms Humans; Female; Double-Blind Method; Male; Middle Aged; Adult; COVID-19; Hyperbaric Oxygenation; Quality of Life; Sweden; SARS-CoV-2; Treatment Outcome; Adolescent; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.