The apoptosis of peripheral blood lymphocytes promoted by hyperbaric oxygen treatment contributes to attenuate the severity of early stage acute pancreatitis in rats. | Canada Hyperbarics Skip to main content
RCT Apoptosis : an international journal on programmed cell death 2014

The apoptosis of peripheral blood lymphocytes promoted by hyperbaric oxygen treatment contributes to attenuate the severity of early stage acute pancreatitis in rats.

Bai X, Song Z, Zhou Y, Pan S, Wang F, Guo Z, et al. — Apoptosis : an international journal on programmed cell death, 2014

View Original on PubMed PMID 24101212
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers randomised 120 male Wistar rats into four groups (sham, acute pancreatitis, AP + normobaric oxygen, AP + hyperbaric oxygen) to investigate the immunoregulatory effects of hyperbaric oxygen on early acute pancreatitis.

What They Found

Hyperbaric oxygen treatment, administered at 2.5 atm for 90 minutes, promoted the apoptosis of peripheral blood lymphocytes and attenuated the severity of early stage acute pancreatitis in rats. This effect was observed in a study involving 120 rats, suggesting a potential immunoregulatory mechanism.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A primary limitation is that this study was conducted in rats, meaning its findings may not directly translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type RCT
Category Decompression Sickness
Source Pubmed
PubMed ID 24101212
Year Published 2014
Journal Apoptosis : an international journal on programmed cell death
MeSH Terms Acute Disease; Animals; Apoptosis; Caspase 3; Caspase 9; Humans; Hyperbaric Oxygenation; Interferon-gamma; Interleukin-10; Lymphocytes; Male; Oxygen; Pancreatitis; Rats; Rats, Wistar

Cite This Study

Share

Related Research

Undersea Hyperb Med | 2014 Review

Hyperbaric oxygen treatment for decompression sickness

Moon RE.
Undersea Hyperb Med | 2019 Clinical Guideline

Hyperbaric treatment for decompression sickness: current recommendations

Moon RE, Mitchell SJ.
Undersea Hyperb Med | 2020 Prospective Study

Avascular necrosis of the femoral head: evaluation of hyperbaric oxygen therapy and quality of life

Chandrinou A, Kapsimali V, Bhatt S, et al.
World Neurosurg | 2025 Systematic Review

Cerebral Air Embolism After Percutaneous Kyphoplasty: A Case Report and Systematic Review of Mechanisms and Management

Fang T, Xue Z, Yang L, He Z, Yang H, Liu H, et al.
Diving Hyperb Med | 2024 Systematic Review

Development of myopia in scuba diving and hyperbaric oxygen treatment: a case report and systematic review

Sokolowski S, Räisänen-Sokolowski A, Lundell R

This study relates to Decompression Sickness. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

See all Decompression Sickness research
View on PubMed Back to Research Library

Find a Canadian Clinic Treating Decompression Sickness

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology