The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial. | Canada Hyperbarics Skip to main content
RCT Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2018

The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial.

Thistlethwaite KR, Finlayson KJ, Cooper PD, Brown B, Bennett MH, Kay G, et al. — Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2018

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomized, double-blind, placebo-controlled trial to assess the effectiveness of hyperbaric oxygen therapy as an adjunct treatment for nonhealing venous leg ulcers.

What They Found

Out of 74 enrolled patients with nonhealing venous leg ulcers, 31 were randomized to receive either 30 hyperbaric oxygen therapy (HBOT) treatments or 30 placebo treatments. At 12 weeks, there was no significant difference between the HBOT and placebo groups in the number of completely healed ulcers.

What This Means for Canadian Patients

For Canadian patients with nonhealing venous leg ulcers, this study suggests that adding hyperbaric oxygen therapy to standard care may not improve ulcer healing rates. Patients should continue to rely on established evidence-based treatments for managing their chronic venous leg ulcers.

Canadian Relevance

This study was not conducted in Canada and does not have a direct Canadian connection.

Study Limitations

The small number of participants (n=31) randomized to the intervention phase limits the generalizability and statistical power of the findings.

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Study Details

Study Type RCT
Category Wound Care
Source Pubmed
PubMed ID 30129080
Year Published 2018
Journal Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
MeSH Terms Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Time Factors; Treatment Outcome; Varicose Ulcer; Wound Healing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.