What Researchers Did
This report discussed the biology of bisphosphonate-related osteonecrosis of the jaws (BRONJ), the potential mechanisms of hyperbaric oxygen (HBO) in its treatment, and the status of ongoing randomised controlled trials investigating HBO efficacy.
What They Found
Researchers found that hyperbaric oxygen (HBO) has the potential to augment bone turnover through signaling effects on osteoclasts, which could be beneficial in treating bisphosphonate-related osteonecrosis of the jaws (BRONJ). While specific numerical outcomes were not presented in this discussion, early results from ongoing randomised controlled trials investigating HBO for BRONJ have been reported as encouraging.
Canadian Relevance
This study has no direct Canadian connection as it discusses research primarily conducted in the United States.
Study Limitations
A limitation of this report is that it discusses ongoing research and potential mechanisms rather than presenting definitive outcomes from a completed randomised controlled trial.