What Researchers Did
Researchers investigated two different radiation dosing schedules to treat carcinoma of the bladder, aiming to overcome the radioresistance of poorly oxygenated cells.
What They Found
A trial with 45 patients with bladder cancer compared two schemes: Scheme I delivered 100 rad three times a day for a total of 8400 rad, and Scheme II delivered 200 rad once a day for a total of 6400 rad. Both schemes included a two-week rest period. The study suggested that Scheme I achieved an improved therapeutic ratio compared to Scheme II.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
This was a preliminary investigation with a relatively small number of patients, limiting the generalizability of the findings.