A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer | Canada Hyperbarics Skip to main content
RCT Ostomy Wound Manage 2013

A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer

Ma L, Li P, Shi Z, Hou T, Chen X, Du J — Ostomy Wound Manage, 2013

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a 2-week randomized controlled study involving 36 diabetic foot ulcer patients, comparing standard care alone to standard care plus twice-daily hyperbaric oxygen therapy.

What They Found

The hyperbaric oxygen (HBO) group showed a significant increase in transcutaneous oxygen pressure (TcPo2) by day 7 (477.8 mm Hg vs 37.06 mm Hg, P <0.01) and day 14 (501.1 mm Hg vs 35.61 mm Hg, P <0.01) compared to baseline. This group also experienced greater ulcer size reduction.

What This Means for Canadian Patients

Canadian patients with diabetic foot ulcers might benefit from hyperbaric oxygen therapy as an adjunct to standard care, potentially leading to improved wound healing. This could reduce complications and improve quality of life for those suffering from chronic foot ulcers.

Canadian Relevance

This study does not have a direct Canadian connection.

Study Limitations

The study's short 2-week duration and small sample size of 36 patients limit the generalizability and long-term implications of the findings.

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Study Details

Study Type RCT
Category Wound Care
Source Pubmed
PubMed ID 23475448
Year Published 2013
Journal Ostomy Wound Manage
MeSH Terms Catalase; Diabetic Foot; Glutathione Peroxidase; Humans; Hyperbaric Oxygenation; Malondialdehyde; Oxidative Stress; Prospective Studies; Superoxide Dismutase; Wound Healing

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.