Prospective Study Lasers in surgery and medicine 2001

Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer--a clinical pilot study.

Tomaselli F, Maier A, Sankin O, Anegg U, Stranzl U, Pinter H, et al. — Lasers in surgery and medicine, 2001

View Original on PubMed PMID 11413551

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Thirty patients with inoperable non-small cell bronchogenic carcinoma and endobronchial stenosis were prospectively studied to investigate the acute effects of combined photodynamic therapy (PDT) and hyperbaric oxygenation (HBO).

What They Found

One and four weeks after treatment, patients reported significant improvement in dyspnea and hemoptysis, and objective subsiding of poststenotic pneumonia. A significant reduction of tumour stenosis (P < 0.05) and an improvement in Karnofsky performance status (P < 0.05) were documented at both time points. No therapy-related complications were observed.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian researchers or patients.

Study Limitations

The small number of patients (n=30) limits the ability to draw definitive conclusions from this pilot study.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Prospective Study
Category	Uncategorised
Source	Pubmed
PubMed ID	11413551
Year Published	2001
Journal	Lasers in surgery and medicine
MeSH Terms	Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hyperbaric Oxygenation; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Pilot Projects; Prospective Studies

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology