Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature | Canada Hyperbarics Skip to main content
Case Report J Mycol Med 2026

Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature

Kapustin P, Munting A, Desgraz B, Menager E, Brühlmann J, Corbaz J, et al. — J Mycol Med, 2026

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Clinicians reported a case of soft tissue mucormycosis (a rare aggressive fungal infection) in an immunocompetent man ankle following a high-energy motorcycle accident, treated with surgery, systemic antifungal drugs, and adjunctive HBOT.

What They Found

The patient was successfully treated with multiple surgical debridements, joint fusion, flap reconstruction, liposomal amphotericin B followed by isavuconazole, and HBOT, with full resolution of the infection. The authors emphasize that all three components were necessary for success.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

Single case report; the relative contribution of HBOT versus surgery and antifungals cannot be determined from one case.

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Study Details

Study Type Case Report
Category Wound Care
Source Pubmed
PubMed ID 41653809
Year Published 2026
Journal J Mycol Med
MeSH Terms Humans; Mucormycosis; Hyperbaric Oxygenation; Male; Antifungal Agents; Combined Modality Therapy; Soft Tissue Infections; Amphotericin B; Debridement; Triazoles; Adult; Mucor; Accidents, Traffic; Surgical Flaps; Pyridines; Nitriles

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology