What Researchers Did
Researchers conducted a systematic review to investigate the efficacy of hyperbaric oxygen (HBO), low-intensity laser (LIL), and platelet-rich plasma (PRP) as adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ).
What They Found
They found that 75.6% of 41 patients treated with HBO showed improvement, while LIL improved symptoms in 64.2% (158 of 246 patients/sites) and achieved complete healing in 39.8% (98 of 246). PRP treatment led to significant symptom improvement in 17.3% (14 of 81 patients) and complete healing in 80.2% (65 of 81 patients).
What This Means for Canadian Patients
These adjuvant therapies, including hyperbaric oxygen, low-intensity laser, and platelet-rich plasma, appear to be safe and effective options for managing medication-related osteonecrosis of the jaws. Patients experiencing MRONJ may benefit from discussing these modalities with their healthcare providers as part of their treatment plan.
Canadian Relevance
This systematic review does not indicate any direct Canadian connection or specific relevance to the Canadian healthcare system.
Study Limitations
A significant limitation of this review is the lack of randomized clinical trials, highlighting the need for more high-quality investigations.