Clinical Study Leukemia research 2007

Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK.

Chen YC, Chen SY, Ho PS, Lin CH, Cheng YY, Wang JK, et al. — Leukemia research, 2007

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers treated hematopoietic (Jurkat, NCI-H929) and non-hematopoietic (A549, MCF-7) cancer cells with hyperbaric oxygen (HBO2) at 2.5 to 3.5 atmosphere absolute (ATA) for 6 hours to investigate apoptosis.

What They Found

They found a significant percentage of apoptosis only in hematopoietic Jurkat and NCI-H929 cells, which also exhibited higher oxidative stress after HBO2 treatment. This treatment led to caspase-3 and caspase-7 activation, further cleavage of PARP, and increased phosphorylation of p38 MAPK in these specific cell types.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or by Canadian researchers.

Study Limitations

A key limitation is that this study was conducted on isolated cancer cell lines in a laboratory setting, not in living patients or animal models.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	17064767
Year Published	2007
Journal	Leukemia research
MeSH Terms	Annexin A5; Apoptosis; B-Lymphocytes; Caspase 3; Caspase 7; Collagen Type XI; Humans; Hyperbaric Oxygenation; Jurkat Cells; Leukemia, T-Cell; Multiple Myeloma; Oxygen; Phosphorylation; Protein Processing, Post-Translational; p38 Mitogen-Activated Protein Kinases

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.