Retrospective Study Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2007

Bisphosphonates and jaw osteonecrosis: the UAMS experience.

Clarke BM, Boyette J, Vural E, Suen JY, Anaissie EJ, Stack BC — Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007

View Original on PubMed PMID 17321866

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Summary

What Researchers Did

Researchers conducted a retrospective chart review of 479 patients to identify 25 individuals who developed osteonecrosis of the jaw (ONJ) while on bisphosphonate therapy.

What They Found

They found that the 25 patients with ONJ had a mean age of 63.4 years, with 40% being female. These patients had been treated with bisphosphonates for an average of 4.4 years, and 42% took steroids while 52% underwent dental work before their ONJ diagnosis.

What This Means for Canadian Patients

Canadian patients taking bisphosphonates should be aware of the potential risk of osteonecrosis of the jaw, especially if considering dental procedures. Open communication with their healthcare providers about bisphosphonate use and any planned dental work is crucial.

Canadian Relevance

This study was conducted in the United States and does not have a direct Canadian connection.

Study Limitations

This retrospective study is limited by its observational nature, single-center data, and small sample size of 25 patients.

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Study Details

Study Type	Retrospective Study
Category	Uncategorised
Source	Pubmed
PubMed ID	17321866
Year Published	2007
Journal	Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
MeSH Terms	Adrenal Cortex Hormones; Anti-Bacterial Agents; Bone Density Conservation Agents; Curettage; Dental Care; Diphosphonates; Female; Humans; Hyperbaric Oxygenation; Imidazoles; Jaw Diseases; Male; Middle Aged; Multiple Myeloma; Osteonecrosis

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.