What Researchers Did
This review article summarized the latest information on how to manage necrotizing soft-tissue infections, including recent data on epidemiology, microbiology, and clinical treatment approaches.
What They Found
The review found that necrotizing soft-tissue infections (NSTI) can be caused by many organisms, with increasing reports of multidrug-resistant bacteria. Morbidity and mortality for NSTI remain high, ranging from 20% to over 30%. The value of additional treatments like intravenous immunoglobulin and hyperbaric oxygen therapy is currently uncertain.
Canadian Relevance
No direct Canadian connection identified.
Study Limitations
A key limitation of this review is the ongoing uncertainty regarding the effectiveness of adjunctive therapies like hyperbaric oxygen, indicating a lack of strong clinical evidence in this area.