Study Transplant Proc 2003

Decreased immunogenicity of human fetal pancreas allografts following hyperbaric oxygen culture

MacKenzie D, Sollinger H, Hullett D — Transplant Proc, 2003

View Original on PubMed PMID 12826204

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated whether culturing human foetal pancreas tissue with hyperbaric oxygen could reduce the immune system's response to it when transplanted.

What They Found

They found that by day 14, human immune cells (CD45 cells) made up less than 2% of cells in grafts treated with hyperbaric oxygen culture. In contrast, nearly 15% of cells in conventionally cultured grafts were human immune cells (P =.0018), with about 75% of these producing an inflammatory marker called IFNgamma. This suggests hyperbaric oxygen culture significantly reduced the immune response.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This study was conducted using an animal model and human cells in a lab setting, meaning the findings may not directly translate to human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Radiation Injury
Source	Pubmed
PubMed ID	12826204
Year Published	2003
Journal	Transplant Proc
MeSH Terms	Animals; Antigens, CD; Diabetes Mellitus, Type 1; Disease Models, Animal; Fetal Tissue Transplantation; Histocompatibility Testing; Humans; Hyperbaric Oxygenation; Leukocyte Common Antigens; Major Histocompatibility Complex; Mice; Mice, Inbred NOD; Organ Culture Techniques; Pancreas; Pancreas Transplantation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Transplantation, Homologous

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This study relates to Delayed Radiation Injury. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology