Study Int J Med Sci 2025

Early Hyperbaric Oxygen Therapy Promotes Recovery of Blunt Liver Injury in Rats via Inhibiting Inflammatory Response and Oxidative Stress

Zhao H, Zhang T, Wang Y, Fang Y — Int J Med Sci, 2025

View Original on PubMed PMID 40303491

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers tested early HBOT in a rat model of blunt liver injury to assess its effects on inflammation, oxidative stress, and tissue healing.

What They Found

HBOT at 2.5 ATA significantly reduced liver enzyme levels, inflammatory markers (IL-1b, IL-6, TNF-a), and oxidative stress indicators while promoting hepatocyte proliferation and accelerating liver function recovery.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

Animal models of traumatic liver injury may not replicate the full spectrum of human blunt abdominal trauma presentations.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	Study
Category	Wound Care
Source	Pubmed
PubMed ID	40303491
Year Published	2025
Journal	Int J Med Sci
MeSH Terms	Animals; Hyperbaric Oxygenation; Oxidative Stress; Rats; Liver; Wounds, Nonpenetrating; Male; Disease Models, Animal; Apoptosis; Humans; Inflammation; Abdominal Injuries

Related Research

Cochrane | 2015 Systematic Review

Hyperbaric oxygen therapy for chronic wounds

Kranke P, Bennett MH, Martyn-St James M, et al.

Ont Health Technol Assess Ser | 2005 Clinical Study ★

Hyperbaric oxygen therapy for non-healing ulcers in diabetes mellitus: an evidence-based analysis

Ontario Medical Advisory Secretariat.

Diabetes Care | 2010 RCT

Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes

Löndahl M, Katzman P, Nilsson A, et al.

Asian J Surg | 2022 Meta-Analysis

Efficacy of hyperbaric oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis

Zhang Z, Yang C, Jiang M, et al.

J Wound Ostomy Continence Nurs | 2017 RCT

Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: a randomized controlled trial

Chen CY, Wu RW, Hsu MC, et al.

This study relates to Problem Wounds. Read the full clinical overview, the evidence base, and Canadian treatment access for this condition.

See all Wound Care research

View on PubMed Back to Research Library

Find a Canadian Clinic Treating Wound Care

Browse verified hyperbaric facilities across Canada.

View Canadian Facilities

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology