Clinical Study PloS one 2017

Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics.

Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, et al. — PloS one, 2017

View Original on PubMed PMID 28542481

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of hyperbaric oxygen therapy (HBOT) on the proliferation, BDNF-release, and secretion of neuroprotective factors from human mesenchymal stem cells (MSCs) and genetically modified NIH3T3 fibroblasts.

What They Found

Researchers found that repeated exposure (3 to 10 times) to 100% oxygen at various pressures influenced the proliferation and neurotrophic factor release from human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts. Conditioned medium from these HBO-treated cells also demonstrated neuroprotective and neuroregenerative effects on spiral ganglion neurons.

Canadian Relevance

This study has no direct Canadian connection or specific relevance to Canadian healthcare policies or patient populations.

Study Limitations

A limitation of this study is its in vitro nature, meaning the findings may not directly translate to complex biological systems in living organisms or human patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	28542481
Year Published	2017
Journal	PloS one
MeSH Terms	Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cell Survival; Cell- and Tissue-Based Therapy; Culture Media, Conditioned; Female; Gene Expression Profiling; Humans; Hyperbaric Oxygenation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; NIH 3T3 Cells

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology