Effectiveness and safety of hyperbaric oxygen therapy for psychiatric disorders: A systematic review and meta-analysis | Canada Hyperbarics Skip to main content
Meta-Analysis Psychiatry Clin Neurosci 2026 Canadian

Effectiveness and safety of hyperbaric oxygen therapy for psychiatric disorders: A systematic review and meta-analysis

Al-Shamali H, Shocker K, Thakkar J, Lin Q, Janssen-Aguilar R, Lou W, et al. — Psychiatry Clin Neurosci, 2026

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers reviewed and combined results from 17 studies to see how hyperbaric oxygen therapy (HBOT) affects adults with psychiatric conditions like depression, anxiety, and PTSD.

What They Found

The review found that HBOT significantly reduced depressive symptoms, showing a large effect (Cohen's d = -0.82), with strong benefits observed at 2.0 ATA but none at 1.2 ATA. It also showed moderate reductions in anxiety (d = -0.59) and a large effect in post-traumatic stress disorder (d = -1.96) in sham-controlled trials. Mild side effects like ear discomfort were reported.

Canadian Relevance

This study has Canadian authors. While it explores conditions like depression, anxiety, and PTSD, these are not currently Health Canada-recognized indications for hyperbaric oxygen therapy.

Study Limitations

The study's findings are preliminary due to variable effects, inconsistent estimates, and the small size of most studies included in the analysis.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Meta-Analysis
Category Neurological
Source Pubmed
PubMed ID 42169234
Year Published 2026
Journal Psychiatry Clin Neurosci

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: May 29, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology