Clinical Study Nitric oxide : biology and chemistry 2015

Effects of hyperbaric oxygen on nitric oxide generation in humans.

Uusijärvi J, Eriksson K, Larsson AC, Nihlén C, Schiffer T, Lindholm P, et al. — Nitric oxide : biology and chemistry, 2015

View Original on PubMed PMID 25498903

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the acute effects of hyperbaric oxygen (HBO2) on nitric oxide (NO) generation in healthy subjects through two experiments measuring exhaled NO, plasma and salivary nitrate/nitrite, and other related biomarkers.

What They Found

Hyperbaric oxygen acutely reduced orally exhaled NO by 30% and nasally exhaled NO by 16%. There was also a marked decrease in the salivary nitrite/nitrate ratio during and after HBO2, suggesting reduced bacterial conversion of nitrate to nitrite and NO.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study was conducted on healthy subjects and focused on acute effects, limiting the generalizability of findings to patient populations or long-term HBO2 exposure.

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Study Details

Study Type	Clinical Study
Category	Uncategorised
Source	Pubmed
PubMed ID	25498903
Year Published	2015
Journal	Nitric oxide : biology and chemistry
MeSH Terms	Adult; Arginine; Breath Tests; Citrulline; Cyclic GMP; Humans; Hyperbaric Oxygenation; Nitrates; Nitric Oxide; Nitrites; Oxygen; Saliva; Tongue; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.