Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: a randomized, sham-controlled trial | Canada Hyperbarics Skip to main content
RCT NeuroImage Clin 2022

Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: a randomized, sham-controlled trial

Zilberman-Itskovich S, Catalogna M, Sasson E, et al. — NeuroImage Clin, 2022

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a randomised, sham-controlled, double-blind trial with 73 post-COVID-19 patients to assess the effects of hyperbaric oxygen therapy on brain connectivity, cognition, and psychological distress.

What They Found

The hyperbaric oxygen therapy group showed decreased internetwork connectivity, which negatively correlated with improvements in attention and executive function scores (p < 0.001). Significant group-by-time interactions were observed in right hippocampal resting state functional connectivity (PFWE = 0.002), and negative correlations were found between psychological distress scores and specific brain connectivity measures (PFWE = 0.012, 0.002).

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The abstract does not explicitly detail study limitations, but the generalizability of these findings to broader populations and long-term efficacy require further investigation.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 36208548
Year Published 2022
Journal NeuroImage Clin

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology